Manuscripts

  • A Novel Anti-Cancer Agent, 1-(3,5-Dimethoxyphenyl)-4-[(6-Fluoro-2-Methoxyquinoxalin-3-yl)Aminocarbonyl] Piperazine (RX-5902), Interferes With b-Catenin Function Through Y593 Phospho-p68 RNA Helicase.
    (Journal of Cellular Biochemistry, 2015, 116, 1595–1601)[Link]
  • A Novel Cytidine Analog, RX-3117, Shows Potent Efficacy in Xenograft Models, even in Tumors that Are Resistant to Gemcitabine.
    (Anticancer Research. 2014, 34, 6951 – 6960)[Link]
  • Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360).
    (Invest New Drugs. 2013 Sep 19.)[Link]
  • Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity.
    (J Med Chem. 2012 May 10;55(9):4521-5. Epub 2012 May 1)[Link]
  • Synthesis, anticancer activity and pharmacokinetic analysis of 1-[(substituted
    2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives.
    (Bioorganic & Medicinal Chemistry 20 (2012) 1303–1309)[Link]
  • Synthesis and anticancer activity of new 1-[(5 or 6-substituted 2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-hetero)arylpiperazine derivatives.
    (Bioorganic & Medicinal Chemistry, November 2010, 18(22,15), 7966-7974)[Link]
  • Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA.
    (European Journal of Medicinal Chemistry, November 2010, 45(11), 5493-5497)[Link]
  • Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents.
    (Bioorganic & Medicinal Chemistry Letters, September 2010 20(17,1), 5277-5281)[Link]
  • Antitumor activity of a novel antisense oligonucleotide against Akt1.
    (Journal of Cellular Biochemistry, November 2009, 108(4) 832–838) [Link]
  • QSID Tool: a new three-dimensional QSAR environmental tool.
    (Journal of Computer-Aided Molecular Design, December 2008, 22(12), 873-883)[Link]
  • In Vivo and In Vitro Effects of a HIF-1a Inhibitor,RX-0047.
    (Journal of Cellular Biochemistry, June 2008, 104(3), 985–994)[Link]
  • SYNTHESIS AND ANTITUMOR ACTIVITY OF FLUOROCYCLOPENTENYL-PYRIMIDINES.
    (Nucleosides Nucleotides Nucleic Acids, 2007, 26(6-7), 713-6)[Link]
  • Requirement of hCenexin for Proper Mitotic Functions of Polo-Like Kinase 1 at the Centrosomes.
    (Molecular and Cellular Biology, November 2006, 26(22), 8316-8335)[Link]
  • Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines.
    (Nucleic Acids Symp Ser, September 2005, 49(1), 107-108)[Link]

Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360)